One pot synthesis of trifluoromethyl aryl sulfoxides by trifluoromethylthiolation of arenes and subsequent oxidation with hydrogen peroxide
Monika Horvat, Gregor Kodrič, Marjan Jereb, Jernej Iskra
Abstract
) with oxidation of aryl trifluoromethyl sulfides using 1.2 equiv. of 30% aqueous hydrogen peroxide and this one-pot process has superior yields than would have been obtained in a two step process.
Topics & Concepts
ChemistryTrifluoromethylSulfoxideHydrogen peroxideArylTrifluoroacetic acidReagentElectrophileOrganic chemistrySolventCatalysisMedicinal chemistryAlkylFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesInorganic Fluorides and Related Compounds