Sequence-Activated Fluorescent Nanotheranostics for Real-Time Profiling Pancreatic Cancer
Yining Tao, Chenxu Yan, Dan Li, Jianfeng Dai, Yingsheng Cheng, Hui Li, Weihong Zhu, Zhiqian Guo
Abstract
behaviors in a sequential fashion. This nanotheranostic with a programmable targeting capability effectively breaks through the PDAC barriers. Ultimately, the released aggregation-induced emission (AIE) particle TCM-U11 directly interacts with PDAC cells and penetrates into the deep tissue. Impressively, this fluorescent nanotheranostic intraoperatively can map human clinical PDAC specimens with high resolution. We believe that this unique sequence-activated fluorescent strategy expands the repertoire of nanotheranostics in the treatment of hypopermeable tumors.
Topics & Concepts
In vivoPancreatic cancerCancer researchPancreatic ductal adenocarcinomaMedicineCancerBiologyInternal medicineBiotechnologyNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials