Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression
Xiling Li, Chun Chien, Yifu Han, Zihan Sun, Xun Chen, Dion Dickman
Abstract
imaging experiments demonstrate that GluClα acts locally at axonal terminals to drive PHD. Unexpectedly, GluClα localizes and traffics with synaptic vesicles to drive presynaptic inhibition through an activity-dependent anionic conductance. Thus, GluClα operates as both a sensor and effector of PHD to adaptively depress neurotransmitter release through an elegant autocrine inhibitory signaling mechanism at presynaptic terminals.
Topics & Concepts
Glutamate receptorHomeostasisChemistryMechanism (biology)Depression (economics)Autocrine signallingNeurosciencePharmacologyBiophysicsEndocrinologyBiologyBiochemistryReceptorEpistemologyMacroeconomicsPhilosophyEconomicsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function