Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
Ian Ferguson, Yu-Hsiu T. Lin, Christine Lam, Hao Shao, Kevin M. Tharp, Martina Hale, Corynn Kasap, Margarette C. Mariano, Audrey Kishishita, Bonell Patiño-Escobar, Kamal Mandal, Veronica Steri, Donghui Wang, Paul Phojanakong, Sami T. Tuomivaara, Byron Hann, Christoph Driessen, Brian Van Ness, Jason E. Gestwicki, Arun P. Wiita
Topics & Concepts
ProteostasisMultiple myelomaProteasomeStable isotope labeling by amino acids in cell cultureBiologyHeat shock proteinCarfilzomibProteasome inhibitorCancer researchCell biologyBiochemistryImmunologyProteomicsGeneHeat shock proteins researchEndoplasmic Reticulum Stress and DiseaseMalaria Research and Control