Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species
Bor-En Jong, Ting‐Shu Wu, Ting‐Shu Wu, Nan-Yu Chen, Cheng-How Yang, Chin‐Chung Shu, Lih-Shinn Wang, Tsu‐Lan Wu, Tsu‐Lan Wu, Jang-Jhih Lu, Cheng‐Hsun Chiu, Hsin‐Chih Lai, Yi‐Teng Hung
Abstract
Macrolides are the mainstays of the antimycobacterial regimens against Mycobacterium abscessus species (formerly Mycobacterium abscessus complex). erm (41) confers inducible macrolide resistance for M. abscessus subsp. bolletii strains, and the majority of M. abscessus subsp. abscessus T28 sequevars. Furthermore, the acquired macrolide resistance of M. abscessus species is due to a point mutation in rrl .
Topics & Concepts
Mycobacterium abscessusrpoBNontuberculous mycobacteriaAmikacinMicrobiologyBiologyBedaquilineTigecyclineMedicineMycobacteriumAntibioticsGeneticsMycobacterium tuberculosisGeneTuberculosisBacteria16S ribosomal RNAPathologyMycobacterium research and diagnosisInfectious Diseases and MycologyTuberculosis Research and Epidemiology