Temperature-modulated selective C(sp<sup>3</sup>)–H or C(sp<sup>2</sup>)–H arylation through palladium catalysis
Thirupathi Gogula, Jinquan Zhang, Madhava Reddy Lonka, Shuaizhong Zhang, Hongbin Zou
Abstract
Unprecedented 16-membered tetramer or [6,5]-fused palladacycle, mutually shadowboxing-like transformed from the shared common intermediate, accomplishes the Pd-catalysed temperature-dependent selective arylation of C(sp<sup>2</sup>)–H or C(sp<sup>3</sup>)–H.
Topics & Concepts
PalladiumCatalysisTetramerChemistryStereochemistryMedicinal chemistryOrganic chemistryEnzymeCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions