Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-<i>a</i>]pyridine Scaffold: SAR of the Biphenyl Moiety
Stefano Sainas, Marta Giorgis, Paola Circosta, Valentina Gaidano, Davide Bonanni, Agnese Chiara Pippione, Renzo Bagnati, Alice Passoni, Yaqi Qiu, Carina F. Cojocaru, Barbara Canepa, Alessandro Bona, Barbara Rolando, Mariia Mishina, Cristina Ramondetti, Barbara Buccinnà, Marco Piccinini, Mohammad Houshmand, Alessandro Cignetti, Enrico Giraudo, Salam Al‐Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco L. Lolli
Abstract
(Jurkat) > 100 μM).
Topics & Concepts
Dihydroorotate dehydrogenaseChemistryPharmacologyMyeloid leukemiaLeukemiaJurkat cellsCytotoxicityIC50StereochemistryPyrimidineIn vitroCancer researchBiochemistryImmunologyT cellMedicineImmune systemBiochemical and Molecular ResearchHIV/AIDS drug development and treatmentCancer therapeutics and mechanisms