Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance
Lipeng Qiu, Jiamin Xu, Kamel S. Ahmed, Mengqin Zhu, Yan Zhang, Miaomiao Long, Weijun Chen, Wenjie Fang, Huijie Zhang, Jinghua Chen
Topics & Concepts
ProdrugDoxorubicinMicelleHyaluronic acidCytotoxicityTumor microenvironmentMultiple drug resistancePharmacologyDrug deliveryIn vivoCancer cellConjugateChemistryCancer researchChemotherapyBiochemistryIn vitroCancerMedicineBiologyInternal medicineOrganic chemistryAqueous solutionAntibioticsMathematical analysisTumor cellsMathematicsBiotechnologyAnatomyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDrug Transport and Resistance Mechanisms