The Genotoxin Colibactin Shapes Gut Microbiota in Mice
Sophie Tronnet, Pauline Floch, Laetitia Lucarelli, D Gaillard, Patricia Martín, Matteo Sérino, Éric Oswald
Abstract
Infections of genotoxic Escherichia coli spread concomitantly with urbanized progression. These bacteria may prompt cell senescence and affect DNA stability, inducing cancer via the production of colibactin, a genotoxin shown capable of affecting host DNA in eukaryotic cells. In this study, we show that the action of colibactin may also be directed against other bacteria of the gut microbiota in which genotoxic E. coli bacteria have been introduced. Indeed, the presence of genotoxic E. coli induced a change in both the structure and function of the gut microbiota. Our data indicate that genotoxic E. coli may use colibactin to compete for gut niche utilization.