Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases
Na Ye, Wangzhi Qin, Sheng Tian, Qingfeng Xu, Eric A. Wold, Jia Zhou, Xue-Chu Zhen
Abstract
selective orthosteric ligands or allosteric modulators.
Topics & Concepts
Allosteric regulationNeuroscienceSigma-1 receptorReceptorChemistrySignal transductionAllosteric modulatorDrug discoveryFunctional selectivityPharmacologyG protein-coupled receptorComputational biologyAgonistPsychologyMedicineBiologyBiochemistryPharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors Study