Novel insights into m<sup>6</sup>A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance
Jinlin Jia, Suwen Wu, Zimo Jia, Chang Wang, Chenxi Ju, Jinxiu Sheng, Fucheng He, Mingxia Zhou, Jing He
Abstract
Accumulating evidence has revealed that m 6 A modification, the predominant RNA modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic and reversible m 6 A modification implements sophisticated and crucial functions in RNA metabolism, including generation, splicing, stability, and translation in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). Furthermore, m 6 A modification plays a determining role in producing various m 6 A-labeling RNA outcomes, thereby affecting several functional processes, including tumorigenesis and progression. Herein, we highlighted current advances in m 6 A modification and the regulatory mechanisms underlying mRNAs and ncRNAs in distinct cancer stages. Meanwhile, we also focused on the therapeutic significance of m 6 A regulators in clinical cancer treatment.