Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues
Danielly C. Ferraz da Costa, Luciana P. Rangel, Mafalda Maria D.C. Martins-Dinis, Giulia D. S. Ferretti, Vı́tor F. Ferreira, Jerson L. Silva
Abstract
This review aims to explore the potential of resveratrol, a polyphenol stilbene, and beta-lapachone, a naphthoquinone, as well as their derivatives, in the development of new drug candidates for cancer. A brief history of these compounds is reviewed along with their potential effects and mechanisms of action and the most recent attempts to improve their bioavailability and potency against different types of cancer.
Topics & Concepts
ResveratrolBioavailabilityChemistryPharmacologyPolyphenolDrugBiochemistryMedicineAntioxidantBioactive Compounds and Antitumor AgentsSynthesis and biological activityCancer therapeutics and mechanisms