The Role of Omentin-1 in Cancers Development and Progression
Paweł Dec, Agata Poniewierska-Baran, Andrzej Modrzejewski, Andrzej Pawlik
Abstract
Adipose tissue serves as an energy store and is also an active endocrine organ, exerting activity that influences obesity-related processes through the production of regulatory proteins called adipokines or adipocytokines. Adipokines play important direct and indirect roles in the pathogenesis of insulin resistance, the regulation of local and systemic inflammatory processes, and related metabolic complications. There have been an increasing number of studies showing the relationship between some adipokines and carcinogenesis. This work reviews the current literature concerning the effects of omentin-1 on carcinogenesis.
Topics & Concepts
AdipokineEndocrine systemAdipose tissueCarcinogenesisInsulin resistanceMedicineObesityCancer researchBioinformaticsInternal medicineEndocrinologyBiologyCancerHormoneAdipokines, Inflammation, and Metabolic DiseasesNutrition and Health in AgingCancer Risks and Factors