Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency
Ji‐Hoon Lee, Seung Woo Ryu, Nicolette A. Ender, Tanya T. Paull
Topics & Concepts
BiologyNeurodegenerationCell biologyCerebellumAtaxia-telangiectasiaDNA damageProtein aggregationSpinocerebellar ataxiaNuclear proteinMutantPoly ADP ribose polymeraseKinaseProtein kinase AMutationTranscription factorGeneticsPolymeraseDNAGeneNeurosciencePathologyMedicineDiseaseDNA Repair MechanismsGenetic Neurodegenerative DiseasesPARP inhibition in cancer therapy