Clinical and molecular characteristics of ARIEL3 patients who derived exceptional benefit from rucaparib maintenance treatment for high-grade ovarian carcinoma
David M. O’Malley, Amit M. Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I. Weberpals, Andrew R. Clamp, Giovanni Scambia, Alexandra Léary, Robert W. Holloway, Margarita Amenedo, Peter C.C. Fong, Jeffrey C. Goh, Elizabeth M. Swisher, Lara Maloney, Sandra Goble, Kevin Lin, Tanya T. Kwan, Jonathan A. Ledermann, Robert L. Coleman
Topics & Concepts
MedicineInternal medicineOncologyClinical trialPARP inhibitorLoss of heterozygosityPlaceboRandomized controlled trialPolymerasePathologyGeneGeneticsPoly ADP ribose polymeraseBiologyAlternative medicineAllelePARP inhibition in cancer therapySirtuins and Resveratrol in MedicineSignaling Pathways in Disease