Sesamin inhibits hypoxia-stimulated angiogenesis <i>via</i> the NF-κB p65/HIF-1α/VEGFA signaling pathway in human colorectal cancer
Yefei Huang, Zixuan Liu, Lin Li, Min Jiang, Yu Tang, Li Zhou, Jing Li, Yansu Chen
Abstract
This study suggests that sesamin can restrain NF-κB p65 to activate HIF-1α transcription under hypoxic conditions, thereby inhibiting VEGFA expression and effectively suppressing colorectal tumor angiogenesis.
Topics & Concepts
AngiogenesisHypoxia (environmental)Signal transductionCancer researchColorectal cancerVascular endothelial growth factor ANF-κBSesaminVEGF receptorsChemistryMedicineCancerVascular endothelial growth factorInternal medicineBiochemistryTraditional medicineOxygenOrganic chemistrySesame and Sesamin ResearchMicroRNA in disease regulationBioactive Compounds in Plants