T-Cell/B-Cell Interactions in Atherosclerosis
Peter William Jones, Ziad Mallat, Meritxell Nus
Abstract
Atherosclerosis is a complex inflammatory disease in which the adaptive immune response plays an important role. While the overall impact of T and B cells in atherosclerosis is relatively well established, we are only beginning to understand how bidirectional T-cell/B-cell interactions can exert prominent atheroprotective and proatherogenic functions. In this review, we will focus on these T-cell/B-cell interactions and how we could use them to therapeutically target the adaptive immune response in atherosclerosis.
Topics & Concepts
Immune systemCellAcquired immune systemB cellImmunologyT cellCell biologyDiseaseBiologyMedicineAntibodyGeneticsInternal medicineAtherosclerosis and Cardiovascular Diseases