Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine
Narciso Couto, Zubida M. Al‐Majdoub, Stephanie Gibson, P. Davies, Brahim Achour, Matthew D. Harwood, Gordon Carlson, Jill Barber, Amin Rostami‐Hodjegan, Geoffrey Warhurst
Topics & Concepts
Organic anion-transporting polypeptideJejunumIleumChemistryTransporterDrug metabolismMediated transportSmall intestineDrugATP-binding cassette transporterAbcg2Solute carrier familyOrganic anion transporter 1Cytochrome P450EnzymeBiochemistryPharmacologyBiologyGeneMembraneDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPharmacogenetics and Drug Metabolism