Photocatalyzed alkylative cyclization of 2-isocyanobiphenyls with unactivated alkyl iodides
Alisha Rani Tripathy, Rizwana Rahmathulla A, Amit Kumar, Veera Reddy Yatham
Abstract
We herein report the first photocatalyzed radical cascade cyclization of 2-isocyanobiaryls with unactivated alkyl iodides. This simple protocol operates under mild reaction conditions and affords 6-alkyl phenanthridines in good yields. To elucidate the reaction mechanism, Stern-Volmer quenching studies were carried out and these studies revealed that the photocatalyst is not directly involved in a single electron transfer process with the alkyl iodide.
Topics & Concepts
ChemistryAlkylIodideQuenching (fluorescence)PhotochemistryCascadeElectron transferCombinatorial chemistryOrganic chemistryFluorescencePhysicsQuantum mechanicsChromatographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques