Structure-guided discovery of novel potent and efficacious proteolysis targeting chimera (PROTAC) degrader of BRD4
Xiang Wang, Qiwei Wang, Kai Ran, Jing Ren, Yao Shi, Luoting Yu
Topics & Concepts
BRD4BromodomainProteolysisChemistryBioavailabilityComputational biologyCancer researchBiochemistryPharmacologyEnzymeBiologyDNAHistoneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways