Anti-Langmuir elution behavior of a bispecific monoclonal antibody in cation exchange chromatography: Mechanistic modeling using a pH-dependent Self-Association Steric Mass Action isotherm
Felix Seelinger, Felix Wittkopp, Thomas von Hirschheydt, Christian Frech
Topics & Concepts
ChemistryElutionSteric effectsChromatographyLangmuir adsorption modelCounterionHydrophobic effectLangmuirIon exchangeAnalytical Chemistry (journal)Aqueous solutionIonStereochemistryPhysical chemistryOrganic chemistryProtein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchAnalytical Chemistry and Chromatography