Rapid Tumor Washout of 177Lu-PSMA Radioligand in Renal Cell Carcinoma
Jingjing Zhang, Christiane Schuchardt, Xiaoyuan Chen, Richard P. Baum
Abstract
ABSTRACT: The role of prostate-specific membrane antigen (PSMA) targeted molecular imaging and radionuclide therapy in prostate cancer is well known. PSMA is also overexpressed in the neovasculature of a number of solid tumors, including renal cell carcinoma (RCC). Several studies have demonstrated the diagnostic utility of PSMA PET imaging in the setting of RCC. To date, no PSMA radioligand therapy of RCC patient has been reported according to literature. Here, we report our experience treating a patient with metastatic RCC with 177 Lu-PSMA I&T radioligand therapy, but unexpected imaging findings with rapid washout of 177 Lu-PSMA from the tumor.
Topics & Concepts
RadioligandMedicineWashoutRenal cell carcinomaProstate cancerGlutamate carboxypeptidase IIRadionuclide therapyClear cell renal cell carcinomaCarcinomaCancer researchNuclear medicinePathologyCancerOncologyInternal medicineReceptorProstate Cancer Treatment and ResearchRadiopharmaceutical Chemistry and ApplicationsRenal cell carcinoma treatment