Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2–associated athanogene 6 (BAG6)
Manish Verma, Jianhui Zhu, Kent Z.Q. Wang, Charleen T. Chu
Abstract
model suggests that PINK1 loss of function represents a point of convergence between the neurotoxic and genetic causes of PD.
Topics & Concepts
PINK1MitochondrionMitophagyBiologyGene knockdownCell biologymitochondrial fusionKinaseCancer researchGeneticsApoptosisMitochondrial DNAAutophagyGeneParkinson's Disease Mechanisms and TreatmentsMitochondrial Function and PathologyGenetic Neurodegenerative Diseases