miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2
Yeong Jin Kim, So Hee Kim, Yega Park, Jiyu Park, Jeong Hoon Lee, Byeong C. Kim, Woo Keun Song
Topics & Concepts
NeurodegenerationDownregulation and upregulationProgrammed cell deathApoptosisBiologyCell biologymicroRNACell cultureCellAlzheimer's diseaseCancer researchPathologyMedicineGeneDiseaseGeneticsMicroRNA in disease regulationAlzheimer's disease research and treatmentsAluminum toxicity and tolerance in plants and animals