Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii
Jennifer M. Colquhoun, Marjan Farokhyfar, Alexander C. Anderson, Christopher R. Bethel, Robert A. Bonomo, Anthony J. Clarke, Philip N. Rather
Abstract
Acinetobacter baumannii has become resistant to all classes of antibiotics, with β-lactam resistance responsible for the majority of treatment failures. New classes of antimicrobials are needed to treat this high-priority pathogen. This study had uncovered a new genetic vulnerability in β-lactamase-expressing A. baumannii, where reduced carbonic anhydrase activity becomes lethal. Inhibitors of carbonic anhydrase could represent a new method for treating A. baumannii infections.
Topics & Concepts
Acinetobacter baumanniiPeptidoglycanCarbonic anhydraseViability assayMutantMicrobiologyBiologyTransposable elementEnzymeBiochemistryGeneChemistryCellBacteriaGeneticsPseudomonas aeruginosaAntibiotic Resistance in BacteriaEnzyme function and inhibitionPhenothiazines and Benzothiazines Synthesis and Activities