Diastereoselective synthesis of dispiro[indoline-3,3′-furan-2′,3′′-pyrrolidine] <i>via</i> [3 + 2]cycloaddition reaction of MBH maleimides of isatins and 1,3-dicarbonyl compounds
Liu‐Na Pan, Jing Sun, Rong‐Guo Shi, Chao‐Guo Yan
Abstract
In the presence of mixed bases DABCO and K<sub>2</sub>CO<sub>3</sub>, the reaction of MBH maleimides of isatins with various cyclic 1,3-dicarbonyl compounds afforded functionalized dispiro[indoline-3,3′-furan-2′,3′′-pyrrolidines] in satisfactory yields and with high diastereoselectivity.
Topics & Concepts
ChemistryIndolineDABCOPyrrolidineFuranIsatinCycloadditionOrganic chemistryMedicinal chemistryOctaneCatalysisOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions