Regio‐ and Diastereoselective Copper‐Catalyzed Carbomagnesiation for the Synthesis of Penta‐ and Hexa‐Substituted Cyclopropanes
Yair Cohen, André U. Augustin, Laura Levy, Peter G. Jones, Daniel B. Werz, Ilan Marek
Abstract
Despite the highly strained nature of cyclopropanes possessing three vicinal quaternary carbon stereocenters, the regio- and diastereoselective copper-catalyzed carbomagnesiation reaction of cyclopropenes provides an easy and efficient access to these novel persubstituted cyclopropyl cores with a complete regio- and diastereoselectivity.
Topics & Concepts
StereocenterVicinalHEXAChemistryCopperCatalysisRegioselectivityStereochemistryEnantioselective synthesisCombinatorial chemistryMedicinal chemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsSynthetic Organic Chemistry Methods