Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage
Hao Wang, Meiling Chen, Xiaohong Sang, Xuefu You, Yucheng Wang, Ian C. Paterson, Wei Hong, Xinyi Yang
Topics & Concepts
Signal transductionSMADTransforming growth factorChemistryCell biologyR-SMADReceptorSmall moleculeCell signalingKinaseSmad2 ProteinCancer researchBiochemistryGrowth factorBiologyTGF alphaTGF-β signaling in diseasesPancreatic and Hepatic Oncology ResearchBone Metabolism and Diseases