Structural Basis for the Allosteric Inhibition of Hypoxia-Inducible Factor 2 by Belzutifan
Xintong Ren, Xiaotong Diao, Jingjing Zhuang, Dalei Wu
Topics & Concepts
Aryl hydrocarbon receptor nuclear translocatorAllosteric regulationTranscription factorChemistryHypoxia-inducible factorsHypoxia-Inducible Factor 1LuciferasePAS domainBasic helix-loop-helixTransfectionMolecular biologyBiologyCancer researchCell biologyBiochemistryReceptorGeneAryl hydrocarbon receptorDNA-binding proteinCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationRenal cell carcinoma treatment