BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade
Jingshan Tong, Xiao Tan, Denise Risnik, Man Gao, Xiangping Song, Kaylee Ermine, Liangfang Shen, Shaomeng Wang, Jian Yu, Lin Zhang
Topics & Concepts
BromodomainCancer researchBiologyImmune checkpointBET inhibitorProtein degradationCarcinogenesisEpigeneticsCancerColorectal cancerImmune systemCell biologyImmunotherapyImmunologyBiochemistryGeneticsGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways