Catalyst and Additive‐Free Direct Amidation/Halogenation of Tertiary Arylamines with <i>N</i>‐haloimide/amides
Xiujuan Xu, Adila Amuti, Abudureheman Wusiman
Abstract
Abstract An approach has been developed for the amidation (halogenation) of tertiary arylamines by electrophilic activation using N ‐haloimide/amides. Several control experiments have been performed, and the coupling reaction outcomes indicated that the N ‐haloimide/amide brings three major functions, including electrophilic activation, aromatic halogenation and nucleophilic nitrogen sources. This cascade reaction features simple manipulation, requires no additional catalyst, oxidant or additives, and is performed under mild conditions. magnified image
Topics & Concepts
HalogenationChemistryElectrophileAmideNucleophileCatalysisOrganic chemistryCombinatorial chemistryCascadeReaction conditionsCascade reactionChromatographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAdvanced Synthetic Organic Chemistry