Homeostatic Function and Inflammatory Activation of Ileal CD8+ Tissue-Resident T Cells Is Dependent on Mucosal Location
Lisanne Lutter, Britt Roosenboom, Eelco C. Brand, José JM ter Linde, Bas Oldenburg, Ellen G. van Lochem, Carmen S. Horjus Talabur Horje, Femke van Wijk
Abstract
BACKGROUND & AIMS: Trm cells, with studies suggesting both proinflammatory and regulatory functions. It is crucial to understand the functional profile of these cells in the context of (new) therapeutic strategies targeting (trafficking of) gut Trm cells. METHODS: Trm cells in healthy control subjects and patients with active ileal Crohn's disease. RESULTS: T cells displayed an innate proinflammatory profile with concurrent loss of homeostatic functions. CONCLUSIONS: Altogether, these compartmental and inflammation-induced differences indicate that therapeutic strategies could have a different impact on the same immune cells depending on the local compartment and presence of an inflammatory milieu, and should be taken into account when investigating short- and long-term effects of new gut T cell-targeting drugs.