PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis
Lifeng Feng, Lini Chen, Weikai Wang, Qi Wei, Minqiang Chen, Xin Jiang, Shiman Hu, Yuchen Wu, Lian Duan, Liyuan Zhu, Xian Wang, Hongchuan Jin
Abstract
During ferroptosis induction, PRMT6 mediated p62 ADMA to promote its phase separation, sequestering Keap1 to activate Nrf2 signaling and inhibit ferroptosis. Therefore, targeting PRMT6-mediated p62 ADMA could be a new option to sensitize ferroptosis for cancer treatment.
Topics & Concepts
Separation (statistics)Negative feedbackLoop (graph theory)ChemistryPhase (matter)Feedback loopCell biologyBiologyComputer sciencePhysicsMathematicsComputer securityMachine learningQuantum mechanicsOrganic chemistryVoltageCombinatoricsCancer-related gene regulationRenal and related cancers