Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target
Xian-Long Fang, Xue-ping Cao, Jun Xiao, Yun Hu, Mian Chen, Hafiz Khuram Raza, Huai-yuan Wang, Xu He, Jinfa Gu, Kang-jian Zhang
Abstract
Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP) family due to its predominant expression in tumours rather than normal terminally differentiated adult tissues. The high expression level of survivin in tumours is closely linked to chemotherapy resistance, heightened tumour recurrence, and increased tumour aggressiveness and serves as a negative prognostic factor for cancer patients. Consequently, survivin has emerged as a promising therapeutic target for cancer treatment. In this review, we delve into the various biological characteristics of survivin in cancers and its pivotal role in maintaining immune system homeostasis. Additionally, we explore different therapeutic strategies aimed at targeting survivin.