JAK-STAT inhibition reduces endothelial prothrombotic activation and leukocyte–endothelial proadhesive interactions
Joan D. Beckman, Angelica DaSilva, Elena L. Aronovich, Aithanh Nguyen, Julia Nguyen, Geneva Hargis, David J. Reynolds, Gregory M. Vercellotti, Brian C. Betts, David K. Wood
Topics & Concepts
RuxolitinibJanus kinasestatJAK-STAT signaling pathwaySTAT proteinMedicineEndothelial stem cellSTAT4Proinflammatory cytokineSTAT1Cancer researchOncostatin MThrombomodulinImmunologySTAT3Signal transductionCytokineInternal medicineInflammationChemistryInterleukin 6MyelofibrosisBiologyCell biologyPlateletInterferonTyrosine kinaseReceptorThrombinBone marrowBiochemistryIn vitroMyeloproliferative Neoplasms: Diagnosis and TreatmentCytokine Signaling Pathways and InteractionsChronic Myeloid Leukemia Treatments