Landscape and age dynamics of immune cells in the Egyptian rousette bat
Virginia Friedrichs, Christophe Toussaint, Alexander Schäfer, Melanie Rissmann, Oliver Dietrich, Thomas C. Mettenleiter, Gang Pei, Anne Balkema‐Buschmann, Antoine‐Emmanuel Saliba, Anca Dorhoi
Abstract
T cells dominate as bats reach adulthood. Despite differing frequencies, phagocytosis of circulating and tissue-resident myeloid cells and proliferation of peripheral and splenic lymphocytes are analogous in juvenile and adult ERBs. We provide a comprehensive map of the immune landscape in ERBs and show age-imprinted resilience progression and find that variability in cellular immunity only partly recapitulates mammalian archetypes.
Topics & Concepts
BiologyImmune systemImmunologyMyeloidJuvenileInnate immune systemTranscriptomeImprinting (psychology)Acquired immune systemImmunityCell biologyGeneticsGeneGene expressionBat Biology and Ecology StudiesViral Infections and VectorsImmune responses and vaccinations