Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO)
Anup Patnaik, Laura Axford, Linhong Deng, Evan Cohick, Xianglin Ren, Sally Loi, Sam Kecman, Micah Hollis‐Symynkywicz, Tyler Harrison, Julien P. N. Papillon, Natalie A. Dales, Lawrence G. Hamann, Lac Lee, Jean B. Regard, Jovita Marcinkeviciene, Martı́n L. Marro, Andrew W. Patterson
Topics & Concepts
MyeloperoxidaseChemistryHypochlorous acidPharmacophoreIndole testIn vivoBiochemistryOxidative stressPharmacologyInflammationImmunologyBiologyBiotechnologyNeutrophil, Myeloperoxidase and Oxidative MechanismsVanadium and Halogenation ChemistryNitric Oxide and Endothelin Effects