Base-mediated ynone-isocyanide [3+2] cycloaddition: a general method to 2,3,4-tri-substituted 1-<i>H</i>-pyrroles and bis-pyrroles
Ankit Kumar, Pawan K. Mishra, Akhilesh K. Verma
Abstract
A general method for the synthesis of functionalized pyrroles and bis-pyrroles from ynones under transition-metal-free conditions in good to excellent yields has been developed.
Topics & Concepts
CycloadditionChemistryYield (engineering)PyrroleIsocyanideCombinatorial chemistrySubstrate (aquarium)Atom economyFunctional groupBase (topology)Organic chemistryCatalysisMaterials sciencePolymerMathematicsMetallurgyGeologyMathematical analysisOceanographySynthesis and Characterization of PyrrolesCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods