Nickel-Catalyzed Direct Cross-Coupling of Aryl Thioether with Aryl Bromide
Nana Ma, Xuan-Bo Hu, Yuan‐Shuai Wu, Ya-Wen Zheng, Mengtao Ma, Xue‐Qiang Chu, Hao Xu, Haiqing Luo, Zhi‐Liang Shen
Abstract
A straightforward cross-coupling of aryl thioether with aryl bromide with the aid of nickel salt, magnesium, and lithium chloride in tetrahydrofuran at ambient temperature was accomplished. The one-pot reactions proceeded efficiently via C-S bond cleavage to produce the desired biaryls in modest to good yields, avoiding the use of pregenerated or commercial organometallic reagents.
Topics & Concepts
ArylChemistryThioetherBromideTetrahydrofuranNickelReagentCatalysisMagnesium bromideMagnesiumBond cleavageChlorideOrganic chemistryCombinatorial chemistryPolymer chemistrySolventAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions