Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors
Ziwei Chi, Ying Bai, Jing Li, KeWei Wang, Yungen Xu, Yepeng Luan
Topics & Concepts
ChemistryAcetylationHistone deacetylasePoly ADP ribose polymeraseHDAC6OlaparibPARP inhibitorBenzimidazoleCancer researchCell growthPharmacologyHistoneBiochemistryPolymeraseEnzymeBiologyDNAOrganic chemistryGenePARP inhibition in cancer therapyHistone Deacetylase Inhibitors ResearchSignaling Pathways in Disease