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Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia

Hannah D. Mason, Yvonne L. Latour, Christopher T. Boughter, Kory Johnson, Dragan Maric, Cayce Dorrier, Vivian A. Guedes, Chen Lai, Patrick C. Duncker, Alexis M. Johnson, Monica Manglani, Jessica Gill, Daniel P. Perl, Martin Meier‐Schellersheim, Dorian B. McGavern

2025Nature Immunology28 citationsDOI

Topics & Concepts

MicrogliaGranzymeTauopathyGranzyme BBiologyCytotoxic T cellNeuroinflammationImmune systemImmunologyCell biologyCD8Cancer researchNeurosciencePerforinInflammationMedicineNeurodegenerationPathologyDiseaseIn vitroBiochemistryNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsImmune Response and Inflammation
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia | Litcius