TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss
Yang Chen, Huaqiang Tao, Haifeng Zhang, Yu Xia, Jiaxiang Bai, Gaoran Ge, Wenming Li, Wei Zhang, Long Xiao, Yaozeng Xu, Zhirong Wang, Ye Gu, Huilin Yang, Yu Liu, Dechun Geng
Abstract
: ACP5/TRAP: acid phosphatase 5, tartrate resistant; ATP6V0D2: ATPase, H+ transporting, lysosomal V0 subunit D2; BCL2: B cell leukemia/lymphoma 2; BECN1: beclin 1, autophagy related; BMs: bone marrow cells; CTSK: cathepsin K; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MMP9: matrix metallopeptidase 9; OVX: oophorectomy; RUNX1: runt related transcription factor 1; SOCS3: suppressor of cytokine signaling 3; SPI1/PU.1: Spi-1 proto-oncogene; TNFSF11/RANKL: tumor necrosis factor (ligand) superfamily, member 11; TET2: tet methylcytosine dioxygenase 2.
Topics & Concepts
BECN1AutophagyOsteoclastGene knockdownBiologySequestosome 1Cell biologyBone resorptionCellular differentiationCancer researchEndocrinologyApoptosisIn vitroBiochemistryGeneBone and Joint DiseasesEpigenetics and DNA MethylationAutophagy in Disease and Therapy