Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy
Yiduo Liu, Han Li, Dejia Dai, Jiakang He, Zhengmin Liang
Abstract
(Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.
Topics & Concepts
Mechanism (biology)Mycobacterium tuberculosisDormancyBiologyTuberculosisGeneMicrobiologyGeneticsMedicinePathologyPhysicsBotanyGerminationQuantum mechanicsMycobacterium research and diagnosisTuberculosis Research and Epidemiology