Padlocking dihydrofurannulation for the control of small degree of helicity built on a fused-tetracyclic core
Arthur Gaucherand, Expédite Yen‐Pon, Diego García‐López, Jean‐Valère Naubron, Sara Chentouf, Michel Giorgi, Stéphane Humbel, Marion Jean, Jean Rodriguez, Damien Bonne
Abstract
the enantioselective organocatalytic domino furannulation of appropriately designed achiral fused-tricyclic precursors resulting in the synthesis of configurationally locked helically chiral tetracyclic scaffolds featuring one or two five-membered rings with the simultaneous control of central and helical chiralities.
Topics & Concepts
HelicityDominoEnantioselective synthesisCore (optical fiber)Combinatorial chemistryMoleculeChemistryStereochemistryPhysicsOrganic chemistryCatalysisParticle physicsOpticsAxial and Atropisomeric Chirality SynthesisAsymmetric Synthesis and CatalysisMolecular spectroscopy and chirality