Copper-Catalyzed Regiospecific Amination of Heteroarenes with Quinoneimides
Weiqiao Lan, Fangyi Liu, Jintao Hu, Jiatong Zhu, Shan Hu, Jie‐Ping Wan, Lihua Liao
Abstract
In this work, an unprecedented and widely applicable strategy for the regioselective C-3 amination of indoles and C-2 amination of heteroarenes (pyrrole and benzofuran) is presented in a simple, high-efficiency way. This protocol is also one of the few methods for the efficient construction of C-N bonds of quinoneimides by the 1,6-addition reaction.
Topics & Concepts
AminationChemistryBenzofuranRegioselectivityCatalysisPyrroleCombinatorial chemistryOrganic chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms