Copper-catalyzed asymmetric propargylic substitution with salicylaldehyde-derived imine esters
Ruo‐Qing Wang, Chong Shen, Xiang Cheng, Xiu‐Qin Dong, Chun‐Jiang Wang
Abstract
-hydroxy group of the salicylaldehyde-derived imine esters is crucial to increase the reactivity and stabilize the azomethine ylide, which may be due to the formation of an intramolecular hydrogen bond between the hydroxyl group and the imine group. A series of synthetic transformations were carried out to access other important chiral compounds, which displayed the synthetic versatility.
Topics & Concepts
SalicylaldehydeImineChemistryCopperCatalysisSubstitution (logic)Medicinal chemistryOrganic chemistryPolymer chemistrySchiff baseProgramming languageComputer scienceCatalytic Alkyne ReactionsSynthetic Organic Chemistry MethodsClick Chemistry and Applications