Perspective on the origin, resistance, and spread of the emerging human fungal pathogen Candida auris

Abstract

Candida auris is a major emerging human fungal pathogen that was first reported in 2009 as an isolate from the ear canal of a patient in Japan Since this initial report, C. auris has grown to represent a "serious threat" in healthcare settings, as indicated by the United States Centers for Disease Control (CDC) and is now on the World Health Organization (WHO) fungal priority pathogen list, described as the "most wanted" critical pathogen However, many questions remain about the emergence, spread, and persistence of C. auris. In particular, the sudden, simultaneous, and independent worldwide emergence of 5 C. auris clades in completely separate geographical regions is a profound puzzle.

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