Regulatory T cells induced by B cells suppress NLRP3 inflammasome activation and alleviate monosodium urate-induced gouty inflammation
Jing‐Hui Huang, Bor‐Luen Chiang
Abstract
via NF-κB signaling. Treg-of-B cells ameliorated gouty inflammation in a mouse air pouch model by reducing neutrophil and leukocyte influx and cytokine and chemokine production. Our results demonstrated that Treg-of-B cells exerted regulatory effects on innate immunity by suppressing NLRP3 inflammasome activation and feasible for future therapeutic applications.
Topics & Concepts
InflammasomeInflammationImmunologyFOXP3ChemokineInnate immune systemChemistryCell biologyBiologyImmune systemInflammasome and immune disordersImmune Cell Function and InteractionIL-33, ST2, and ILC Pathways