Targeting inosine metabolism to enhance EGFR-targeted therapy in lung adenocarcinoma
Xiaolong Huang, Jiaqi Liang, Yanjun Yi, Junkan Zhu, Han Lin, Shencheng Ren, Cheng Tao, Guoshu Bi, Guangyao Shan, Dejun Zeng, Fengkai Xu, Di Ge, Cheng Zhan
Topics & Concepts
InosineCancer researchTyrosine kinaseBiologyPurine nucleoside phosphorylaseAdenosineTyrosine-kinase inhibitorKinasePurine metabolismPharmacologyReceptor tyrosine kinaseAdenocarcinomaSignal transductionEpidermal growth factor receptorMedicineProgrammed cell deathPurineCisplatinChemistryLungReceptorAdenosine and Purinergic SignalingRNA modifications and cancerCalcium signaling and nucleotide metabolism