Tolerance to Hypoxia Is Promoted by FOXO Regulation of the Innate Immunity Transcription Factor NF-κB/Relish in <i>Drosophila</i>
Elizabeth C. Barretto, Danielle M Polan, Amy N Beevor-Potts, Byoungchun Lee, Savraj Grewal
Abstract
mutant animals show reduced survival in hypoxia. Together, these data indicate that FOXO is a hypoxia-inducible factor that mediates tolerance to low oxygen by inducing immune-like responses.
Topics & Concepts
BiologyTranscription factorInnate immune systemImmunityNF-κBHypoxia (environmental)Transcription (linguistics)GeneticsCell biologyHypoxia-inducible factorsImmunologyGeneOxygenSignal transductionImmune systemLinguisticsPhilosophyChemistryOrganic chemistryPhysiological and biochemical adaptationsInvertebrate Immune Response MechanismsAdipose Tissue and Metabolism